Phosphorylation Toggles the SARS-CoV-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States
Bruna Favetta, Huan Wang, Jasmine Cubuk, Arjun Singh, Mayur Barai, Cesar Ramirez, Haiyan Zheng, Adam J. Gormley, N. Sanjeeva Murthy, Gregory L. Dignon, Andrea Soranno, Zheng Shi, Benjamin S. Schuster
This study shows phosphorylation of SARS-CoV-2 N protein toggles its condensate state between membrane-wetting and engulfment, revealing a regulatory mechanism for viral RNA replication and packaging.
Nature Communications · Aug 26, 2025Peer-reviewedBiophysics