Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging
Huiyong Cheng, Dawson Miller, Nneka Southwell, Paola Porcari, Joshua L. Fischer, Isobel Taylor, J. Michael Salbaum, Claudia Kappen, Fenghua Hu, Cha Yang, Kayvan R. Keshari, Steven S. Gross, Marilena D’Aurelio, Qiuying Chen
The paper develops an R package for pixel-by-pixel ratio imaging of metabolite pairs in mass spectrometry imaging, enhancing spatial contrast and revealing new tissue regions and biomarkers.
eLife · Mar 18, 2025Peer-reviewedBioinformatics