IFNγ and proinflammatory cytokines cooperatively license astrocytes to support antigen-dependent CD4+ T cell restimulation
Theodore M. Fisher, Francesco Limone, Matthew D. Smith, Chandler Wright, Petra Kukanja, Peiwen Lu, Kerry C. Limberg, Nicolette Pirjanian, Jimena Zulueta, Valentina Fossati, Akiko Iwasaki, Peter A. Calabresi, Shane Antony Liddelow
The paper shows that IFNγ and proinflammatory cytokines activate astrocytes to express antigen-presenting machinery, supporting CD4+ T cell restimulation in vitro and in vivo.
Cell Reports · Oct 29, 2026Peer-reviewedNeuroscience