A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis
Bhagawati Jalnapurkar, David Le, William Shainin, Ryan Zarcone, Rajat Bhatnagar, Joshua Chin, Conor K. Corbin, Charles Curt, Brian A. Hodge, Fernando Martinez, Thomas Mikita, Anne Pipathsouk, Jesse Rosen, Thomas A. Rando, Joseph T. Rodgers, Jeremy W. Linsley
The paper develops a deep learning platform to screen compounds for ALS treatment using age-relevant human motor neurons and identifies NCB-0846 as a potential therapeutic.
bioRxiv · Nov 21, 2023 · PreprintNeuroscience