Benchmarking single-cell foundation models for aging biology
Xiaomin Ni, Yunhao Liang, Jialin Zhu, Luoxi Zhang, Shen Xingyu, Min Yang, Xu Ruifeng, Hui Li, Rongrong Ji, Chen Jin, Shiwen Ni
This study benchmarks single-cell foundation models for aging biology, finding that Geneformer excels in age prediction and pseudotime concordance, while SCimilarity outperforms others in rare state identification.
bioRxiv · Sep 27, 2026 · PreprintBioinformatics