Hui Li

ClearGel: a thermoresponsive hydrogel for chronic, near-millimeter two-photon imaging through the intact skull

ClearGel enables chronic, near-millimeter two-photon imaging through the intact skull in live mice with high resolution and reversibility.

Stromal control of sympathetic rewiring in metastatic lymph nodes

This study shows that tumor-driven remodeling of metastatic lymph nodes involves sympathetic neural rewiring mediated by stromal HGF and mechanical cues.

Decomposing polygenic risk of coronary artery disease into distinct biological processes

The paper decomposes polygenic risk of coronary artery disease into distinct biological processes using latent factor decomposition of genetic variants.

Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice

This study links changes in cerebral energy efficiency metrics to neural network reorganization in mice under different states.

Impaired astrocytic Cx43 syncytial network in lateral habenula affects synaptic connectivity and drives adolescent stress-induced depression

This study identifies impaired astrocytic Cx43 syncytial networks in the lateral habenula as a driver of adolescent stress-induced depression through disrupted synaptic connectivity and neuronal function.

Pervasive Backdoor Vulnerabilities in Genomic Foundation Models

This study identifies backdoor vulnerabilities in genomic foundation models through data poisoning during fine-tuning and proposes an auditing framework to detect such threats.

Benchmarking single-cell foundation models for aging biology

This study benchmarks single-cell foundation models for aging biology, finding that Geneformer excels in age prediction and pseudotime concordance, while SCimilarity outperforms others in rare state identification.

Age-Associated Remodeling of neuroglial Connexin43 in the Mouse and Human Brain

The paper identifies a non-linear aging trajectory of Connexin43 in mouse and human brains, showing midlife elevation followed by late-life decline and glial remodeling.

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.

TRIO-AI: Hybrid temporal graph, ODE, and VAE modeling for high-resolution cellular trajectory inference in liver injury

TRIO-AI identifies a transitional macrophage population in liver injury using a hybrid model of temporal graphs, ODEs, and VAEs, revealing key signaling pathways and spatial localization.

Land plant-specific H3K27 methyltransferases ATXR5 and ATXR6 control plant development and stress responses

This study shows that ATXR5/6 methyltransferases are essential for plant development and stress responses, maintaining H3K27me3 and repressing stress-responsive genes in Arabidopsis and rice.

Gene Editing and Aging: A Bibliometric Analysis of Global Trends and Frontier Themes (2015-2024)

This study performs a bibliometric analysis of gene editing and aging research from 2015 to 2024, identifying key trends and future directions.

Mechanical cues of extracellular matrix determines tumor innervation

This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.

CNA Explorer and anaLyzer (CNAEL): an interactive web application and standard operating procedure enabling efficient clinical review and reporting of complex NGS-derived tumor copy number profiles

CNAEL is a web application and protocol that streamlines clinical analysis and reporting of NGS-derived tumor copy number profiles, reducing curation time significantly.

Counter-stimuli Inhibit GRPR Neurons via GABAergic Signaling in the Spinal Cord

This study identifies GRPR neurons as key itch-transmitting neurons in the spinal cord and shows that counter-stimuli inhibit them via GABAergic signaling.

Gene mapping of nine agronomic traits and genome assembly by resequencing a foxtail millet RIL population

This study resequences a foxtail millet RIL population to improve genome assemblies and map genes for nine agronomic traits.