Endothelial iron homeostasis regulates BBB integrity via the HIF2α-Ve-cadherin pathway
Daniel Rand, Orly Ravid, Dana Atrakchi, Hila Israelov, Yael Bresler, Chen Shemesh, Liora Omesi, Sigal Liraz Zaltsman, Fabien Gosselet, Taber S. Maskrey, Michal Schnaider Beeri, Peter Wipf, Itzik Cooper
This paper investigates how endothelial iron homeostasis affects BBB integrity through the HIF2α-Ve-cadherin pathway, identifying DFO and JP4-039 as potential therapeutic agents.
bioRxiv · Oct 28, 2020 · PreprintNeuroscience