Author

Chen Yu

Shenzhen Bay LaboratoryPrimary ORCID profile (0000-0001-8425-9930 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Chen YuiD1 paper · University of Rochester Medicine

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

Bin ZhouiD· 1 shared Chao LiangiD· 1 shared Dinglin Luo· 1 shared Dong GaoiD· 1 shared Fan ruipeng· 1 shared Han zhenhao· 1 shared Hongjiong Zhang· 1 shared Jiguang WangiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperDevelopmental Biology

Bin ZhouORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multimodal integration of single cell ATAC-seq data enables highly accurate delineation of clinically relevant tumor cell subpopulations

Kewei Xiong, Wei Wang, Ruofan Ding, Dinglin Luo, Yangmei Qin, Xudong Zou, Jiguang Wang, Chen Yu, Lei Li

MAAS integrates multimodal scATAC-seq data to identify clinically relevant tumor subpopulations and improve prognostic prediction.

Genome Medicine · Jan 13, 2026Peer-reviewedBioinformatics

Leveraging defense system modularity to discover anti-phage systems

Liu yanqiu, Tan keyi, Han zhenhao, Chen yu, Xiao kangyi, Luo pian, Fan ruipeng, Liang fuming, Rafael Pinilla‐Redondo, Wenyuan Han

The paper identifies new anti-phage defense systems in E. coli by analyzing modular defensive domains, validating several candidates with anti-phage activity.

bioRxiv · Dec 8, 2025 · PreprintMicrobiology

Dysfunction of microglia-mediated synaptic pruning in Autism spectrum disorder

Chen Yu, Xiao‐Peng Zhang, Wei Wang

This study investigates how microglia-mediated synaptic pruning is disrupted in ASD by integrating inflammatory and synaptic signaling pathways, showing that reduced synaptic activity and pro-inflammatory activation lead to excessive synaptic accumulation.

bioRxiv · Jul 20, 2025 · PreprintSystems Biology

Intermediate basal cell population in prostate homeostasis and cancer initiation

Wangxin Guo, Xiaoyu Zhang, Lin Li, Pengfei Shao, Hongjiong Zhang, Kuo Liu, Chao Liang, Shuoming Wang, Yunyi Peng, Yi Ju, Chen Yu, Luonan Chen, Bin Zhou, Dong Gao

The paper identifies an intermediate basal cell population (Basal-B) in the prostate that shows lineage plasticity and contributes to both homeostasis and cancer initiation.

bioRxiv · May 12, 2023 · PreprintDevelopmental Biology