Dong Gao

This study shows that luminal prostatic epithelial cells depend on AR signaling for survival and differentiation, and their loss triggers compensatory pathways and lineage plasticity.

ODFormer predicts personalized drug responses in pancreatic cancer by simulating patient-derived organoids using transcriptomic and mutational data, outperforming existing methods and improving clinical outcomes.

This study identifies statins as effective in targeting chemoresistant pancreatic cancer by inhibiting cholesterol metabolism and protein glycosylation, showing clinical benefit in a phase 2 trial.

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

The paper identifies an intermediate basal cell population (Basal-B) in the prostate that shows lineage plasticity and contributes to both homeostasis and cancer initiation.

The paper shows that YAP activation in Procr+ ovarian progenitors is essential for OSE repair and stem/progenitor expansion through reduced Vgll4 expression and increased Procr transcription.