Fibroblast-encoded inflammatory memory orchestrates recurrent skin inflammation via NNMT-dependent metabolic remodeling
Yifan Zhou, Kang Li, Yuming Xie, Chencan Su, Zhiguo Li, Yang Yang, Pei Qiao, Wanting Liu, Yaxing Bai, Ke Xue, Johann Gudjonsson, Gang Wang, Shuai Shao
This paper identifies NNMT as a metabolic-epigenetic regulator in fibroblasts that sustains inflammatory memory and drives recurrent skin inflammation by maintaining a pro-inflammatory niche.
bioRxiv · Apr 30, 2026 · PreprintImmunology