Spatially resolved multimodal hallmarks of response to neoadjuvant immunotherapies in the melanoma ecosystem in 2D and 3D
Zichao Liu, Xiaofei Song, Wei-Shen Chen, Shikhar Dhingra, Jiang He, Lizhi He, Chengyi Chen, Jodi A. Balasi, Zena Sayegh, Carlos M. Moran Segura, Neale Lopez-Blanco, Anthony E. Alleyne, Jonathan V. Nguyen, Joseph Johnson, Douglas C. Marchion, , Pei-Ling Chen
The paper analyzes the spatial molecular architecture of melanoma tumors under different immunotherapy regimens and identifies biomarkers predicting response to treatment.
bioRxiv · Sep 18, 2026 · PreprintCancer Biology