Chia Li

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons

This study identifies that semaglutide induces weight loss via cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons through both Gs- and Gq-signaling pathways.

Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety

The paper identifies a neural circuit involving TrhArc neurons that mediate the appetite-suppressing effects of GLP-1RAs by inhibiting AgRP neurons.

A Hypothalamic Circuit that Modulates Feeding and Parenting Behaviors

This study identifies a hypothalamic circuit involving ARCAgRP and MPOABRS3 neurons that modulates the prioritization of feeding and parenting behaviors during lactation.

AgRP neurons coordinate the mitigation of activity-based anorexia

This study identifies AgRP neuron activity as a key factor in activity-based anorexia and shows that activating these neurons can mitigate the condition.

Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways

The paper identifies POA BRS3 neurons that increase body temperature and heart rate through multiple pathways, revealing their role in thermoregulation and cardiovascular control.

Kappa opioid receptor modulation on GABAergic inputs onto ventral periaqueductal gray dopamine neurons

This study investigates how KOR activation affects GABAergic inputs to vlPAG dopamine neurons and identifies a pre-synaptic mechanism involving G-protein βγ subunits.