Italia: A PARP-Directed Auger Electron-Emitting Agent for Targeted Radionuclide Therapy of Cancer
Sreelakshmi Unnikrishnan, Chiara Rua, G.C. Li, Nerea Delgado Mayenco, Luis Hernández Cano, Gulbahar Bozan, Ilias Patmanidis, Sangwani Simwaka, Ahmad Kurniawan, Wiktor Szymański, Erik F. J. de Vries, Philip H. Elsinga, Ines Farinha Antunes, Gianluca Destro, Bart T. Cornelissen
This paper describes the design, synthesis, and evaluation of [123I]Italia, a PARP-targeted radionuclide therapy agent showing potent PARP1 inhibition and cancer cell uptake.
bioRxiv · Mar 17, 2026 · PreprintCancer Biology