Elimination of intramuscular immunoglobulin accumulation alleviates Duchenne Muscular Dystrophy
Li Zhang, Wenting Guo, Mei Huang, Z Y Liang, Enni Zhu, Geng Li, Chong Chang, X S Guo, Wenjie Sun, Jia Li, J S Liu, Han Qiu, L C Zhu, Shuaiwei Ren, Raoxian Bai, , Xing Chang
This study identifies IgG accumulation in dystrophin-deficient muscle as a driver of DMD progression and shows that B cell depletion reduces it, offering a potential therapeutic strategy.
bioRxiv · Feb 12, 2026 · PreprintImmunology