SPEAR: Spatial Epitranscriptomic Analysis by Mass Spectrometry Reveals Localized RNA Modification Remodeling During Glioma Progression
Stéphanie Mateus, Aurore Attina, Kévin Bigot, Valérie Rigau, Jérôme Vialaret, Christophe Hirtz, Amélie Darlix, Chris Planque, Alexandre David
SPEAR combines laser microdissection and LC-MS/MS to enable spatial epitranscriptomic profiling of FFPE tissue, revealing RNA modification changes in glioma progression.
bioRxiv · Oct 16, 2026 · PreprintCancer Biology