Cancer BiologybioRxivPreprint
TMEM Doorway Mediated Metastasis in Pancreatic Ductal Adenocarcinoma by Tie2 Signaling
Érika Pereira Zambalde, Lina A. Ariyan, Francisco Puerta-Martinez…·John C. McAuliffe
This study identifies TMEM doorways as a mechanism for metastasis in PDAC, showing Tie2 macrophages facilitate intravasation and that targeting Tie2 improves survival in mouse models.