Hava Gil-Henn

This study shows that Mena promotes KRAS-driven pancreatic tumor growth and metastasis by enhancing oncogenic signaling pathways.

This study identifies TMEM doorways as a mechanism for metastasis in PDAC, showing Tie2 macrophages facilitate intravasation and that targeting Tie2 improves survival in mouse models.

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.

This study shows that PYK2 and FAK regulate breast cancer metastasis through distinct mechanisms, with PYK2 affecting motility and FAK reducing tumor size and metastasis.

The paper investigates the effect of arginase inhibition with norvaline on adult neurogenesis in Alzheimer's disease mice, finding increased neuronal survival and molecular markers of maturation.

This study evaluates L-norvaline's neuroprotective effects in an AD mouse model, finding it reverses cognitive decline and reduces beta-amyloidosis and microgliosis.

This study shows that L-norvaline improves spatial memory and reduces amyloid-beta in Alzheimer's mice by inhibiting arginase and S6K1 pathways.