In-Solution Measurements of Binding Kinetics and Thermodynamics by nano Temperature Alteration Kinetics
Andreas Langer, Christian Osseforth, Philipp Schramm, Mariam Mohamadi, Nils-Eric Guenther, Oscar Reinecke
This paper introduces nanoTAK, a method to measure fast binding kinetics and thermodynamics using spectral shifts, validated across DNA, protein-ligand, and PROTAC systems.
bioRxiv · Oct 28, 2026 · PreprintBiophysics