Structural and Thermodynamic Impact of Oncogenic Mutations on the Nucleosome Core Particle
Augustine C. Onyema, Christopher DiForte, Rutika Patel, Sébastien F. Poget, Sharon M. Loverde
This study examines how two oncogenic histone mutations affect nucleosome stability through molecular dynamics simulations and biophysical assays, showing reduced interface stability and altered thermal properties.
Biophysical Journal · Jun 14, 2025Peer-reviewedBiophysics