Pre-injury subchronic stress confers sex-specific protection against pain-associated symptoms in osteoarthritic mice
Roxana Florea, Samuel Singleton, Laura Andreoli, Sara Hestehave, Christopher J. Black, Sandrine M. Géranton
This study shows that pre-injury stress in male mice reduces pain symptoms in osteoarthritis, while increasing them in females, revealing sex-specific effects of stress on pain resilience.
bioRxiv · Mar 2, 2026 · PreprintNeuroscience