Christopher J. Ward

Targeting glucocorticoid signalling in dendritic cells for glioblastoma treatment

This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.

Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cell dysfunction in human cancer

This study identifies GR-RUNX cooperation in driving CD8 T cell dysfunction in human cancer through transcriptional and chromatin analyses.

Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

Local glucocorticoid signalling promotes pancreatic cancer

This study identifies Hsd11b1 as a key enzyme promoting glucocorticoid signaling in pancreatic cancer, contributing to immunosuppression and fibrosis, suggesting HSD11B1 as a therapeutic target.