Natalie Z M Homer

This study shows that 18F-fluorocholine PET can detect human brown adipose tissue at room temperature by measuring phosphatidylcholine synthesis, without requiring cold exposure.

This study identifies glucocorticoid signalling as a barrier to dendritic cell immunotherapy in glioblastoma and shows that targeting NR3C1 can restore DC function and enhance anti-tumor responses.

This study investigates corticosterone metabolism and dynamics in humans, finding it has faster turnover, greater metabolism, and a stronger ACTH response compared to cortisol.

This study uses mass spectrometry imaging to map corticosteroid distribution in mouse kidneys, revealing regional localization patterns and dietary salt effects on corticosterone levels.

This study shows that inhibiting 11βHSD1 after myocardial infarction preserves cardiac function and prevents adverse remodelling in a mini-pig model.

This study identifies Hsd11b1 as a key enzyme promoting glucocorticoid signaling in pancreatic cancer, contributing to immunosuppression and fibrosis, suggesting HSD11B1 as a therapeutic target.

The paper identifies Posaconazole as a CYP11A1 inhibitor that enhances anti-tumour immunity in a mouse model of lung metastasis.

This study identifies de novo steroidogenesis in mast cells as a novel regulatory mechanism essential for their development, survival, and function, with implications for inflammatory and anaphylactic responses.

This study identifies CBR1 as a regulator of blood pressure in Down Syndrome, showing that its inhibition can increase blood pressure in a DS mouse model.

This study shows that ABCC1 deficiency in male mice affects glucose metabolism and insulin tolerance on a high-fat diet without altering tissue corticosterone levels.

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

This study investigates the effects of RL-118, an 11β-HSD1 inhibitor, on cognitive and molecular changes induced by chronic mild stress in SAMP8 mice, showing restoration of stress-induced impairments.