Christopher Webb Thomas

Investigating the Effects of Psilocybin on Cognitive Flexibility in Touchscreen and Naturalistic Variations of the Probabilistic Reversal Learning Task

This study examines the acute and post-acute effects of psilocybin and LSD on cognitive flexibility in rats using two probabilistic reversal learning tasks, finding no robust enhancement of reversal learning.

Distinct Modulatory Effects on Affective Biases by Different Serotonergic Psychedelics and MDMA in Male Rats: Possible Implications for Antidepressant Effects

This study investigates how different serotonergic psychedelics and MDMA affect affective biases in male rats, finding varied impacts on memory and new experiences that may relate to their antidepressant potential.

Inhibition of cortico-amygdala projections underlies affective bias modification by psilocybin

This study identifies modulation of the prelimbic cortico-amygdala circuit by psilocin as key to affective bias modification and antidepressant effects in a rodent model.

Psilocybin rapidly, but not immediately, reverses reward learning deficits in a durable manner in an inflammatory rat model of depressive symptoms

Psilocybin reverses reward learning deficits in a rat model of depression within 24 hours, with effects lasting at least 7 days.