Biphasic Temporal Remodeling Of The Proteome In A Polyglutamine-Expanded Huntingtin In Vitro Aggregation Cell Model: From Early Rna-Regulatory Compensation To Selective Mitochondrial Energy Failure
Ekin Sönmez, Pınar Mutlu, Cinla Ozlevent, Mehmet Sarıhan, Gürler Akpınar, Murat Kasap, Hüseyin Çimen
This study identifies a biphasic proteomic remodeling in a Huntington's disease cell model, showing early RNA regulatory compensation and late mitochondrial failure, with potential drug targets identified.
bioRxiv · Aug 24, 2026 · PreprintSystems Biology