A Marfan-Associated FBN1 Nonsense Mutation Mouse Model Reveals Adventitial Inflammation During Aneurysm Progression
Shichao Wu, Jiawei Zhao, Alejandro Ponce, Lucynda Pham, Daniel Xie, Donghong Ju, Shuping Yin, Francis Hernandez, Sean Jones, Clair Li, Charles S. Chung, Dragana Komnenov, Noreen F. Rossi, Dogukan Mizrak, Bo Yang, , Li Li
This paper develops a mouse model with a FBN1 nonsense mutation to study aneurysm progression, finding that adventitial inflammation contributes to aortic aneurysm rupture.
bioRxiv · Sep 23, 2025 · PreprintGenetics