Seed Amplification Assay-Based Detection of Alpha-Synuclein Aggregates Outperforms Immunohistochemical Analysis in the Intestinal Mucosal Biopsies of Parkinson's Disease and Multiple System Atrophy Participants
Ali Keshavarzian, Phillip A. Engen, Claudio Soto, Robin M. Voigt, Bryan Killinger, Maliha Shaikh, Michelle A. Pinho, Sandra Pritzkow, Jayda B. Duvernay, Mariah K. Barnett, Stefan J. Green, Mohamed Abdel-Mohsen, Amol Sharma, Christopher G. Goetz
This study compares a seed amplification assay for alpha-synuclein aggregates with immunohistochemistry in intestinal biopsies of Parkinson's disease and multiple system atrophy patients, finding the assay detects aggregates more frequently and with higher specificity.
bioRxiv · Nov 6, 2026 · PreprintNeuroscience