NeurosciencebioRxivPreprint
Seed Amplification Assay-Based Detection of Alpha-Synuclein Aggregates Outperforms Immunohistochemical Analysis in the Intestinal Mucosal Biopsies of Parkinson's Disease and Multiple System Atrophy Participants
Ali Keshavarzian, Phillip A. Engen, Claudio Soto…·Christopher G. Goetz
This study compares a seed amplification assay for alpha-synuclein aggregates with immunohistochemistry in intestinal biopsies of Parkinson's disease and multiple system atrophy patients, finding the assay detects aggregates more frequently and with higher specificity.
DOI 10.64898/2026.11.05.764662