NRF2-Dependent Anti-Inflammatory Activity of Indole via Cell Surface Receptor Signaling in Murine Macrophages
Clint Cheng, Siddanagouda R. Shivanagoudra, Aniruddh Mukunth, Sumathi Biradar, Yadeliz A. Serrano Matos, Cory L. Klemashevich, Da Mi Kim, Gus A. Wright, Sweta Ghosh, Venkatakrishna Rao Jala, Stephen H. Safe, Robert Christopher Alaniz, Arul Jayaraman
This study shows an indole conjugate inhibits inflammation in macrophages via NRF2-dependent surface receptor signaling.
bioRxiv · Dec 23, 2025 · PreprintCell Biology