Author

Colin Staab

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:scRNA-seq· 1

Frequent Co-Authors

Li‐Huei TsaiiD· 5 shared Oisín KingiD· 4 shared Alan Y. L. JiangiD· 3 shared Alice E. StantoniD· 3 shared Emre Agbas· 3 shared Liwang Liu· 3 shared Nhat Truong· 3 shared Rebecca L. PinalsiD· 3 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersNeuroscience

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5 papers

Recent·Most cited

DNA double-strand break signaling induces aberrant neuronal activity

Ping‐Chieh Pao, Liwang Liu, Lauren Ashley Watson, Audrey Lee, Alexander Seguin, Daiyun Dong, Samaa Rasheed, Colin Staab, Oisín King, Ute Geigenmüller, Jay Penney, Fan Gao, Abdurrahman Muhtaseb, Ravikiran M. Raju, Li‐Huei Tsai

This study shows that p53 activation via DNA damage response causes aberrant neuronal activity in neurodegenerative diseases, and inhibiting p53 reduces this activity in a human iPSC model.

bioRxiv · May 13, 2026 · PreprintNeuroscience

Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

Alice E. Stanton, Adele Bubnys, Emre Agbas, Benjamin T. James, Dong Shin Park, Alan Y. L. Jiang, Rebecca L. Pinals, Liwang Liu, Nhat Truong, Anjanet R. Loon, Colin Staab, Oyku Cerit, Hsin-Lan Wen, David V. Mankus, Margaret E. Bisher, , Li‐Huei Tsai

The paper constructs a 3D human brain model integrating multiple cell types to study Alzheimer's Disease mechanisms linked to APOE4.

Proceedings of the National Academy of Sciences · Oct 17, 2025Peer-reviewedNeuroscience

Inflammatory reprogramming of human brain endothelial cells compromises blood-brain barrier integrity in Alzheimer's disease

Rebecca L. Pinals, Rezaul Islam, Oisín King, Aaron Choi, Eulim Kang, Masayuki Nakano, Anjanet Tuyeras, Maeesha Tasnim Naomi, Arthur Ngo, Alan Y. L. Jiang, Nhat Truong, Emre Agbas, Claudia F. Lozano Cruz, Colin Staab, Tak Ko, , Li‐Huei Tsai

This study identifies an inflammation-driven gene module in brain endothelial cells that compromises BBB integrity in Alzheimer's disease and shows that an NF-κB inhibitor can reverse these effects.

bioRxiv · Sep 26, 2025 · PreprintNeuroscience

Vascular-Perfusable Human 3D Brain-on-Chip

Alice E. Stanton, Rebecca L. Pinals, Aaron Choi, Nhat Truong, Eulim Kang, Alan Y. L. Jiang, Claudia F. Lozano Cruz, Sydney Hawkins, Ryana Sarcar, Alexandra Volkova, Oisín King, Emre Agbas, Masayuki Nakano, Ching‐Chi Chiu, Adele Bubnys, , Li‐Huei Tsai

The paper develops a 3D Brain-Chip system using human iPSC-derived cells to model the BBB and study APOE4's role in Alzheimer's disease.

bioRxiv · Sep 18, 2025 · PreprintNeuroscience

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, , Li‐Huei Tsai

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

bioRxiv · Sep 5, 2023 · PreprintNeuroscience