Author

Tak Ko

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Li‐Huei TsaiiD· 2 shared Aaron Choi· 1 shared Adam Officer· 1 shared Alan Y. L. JiangiD· 1 shared Alejandro Borja Grau-PeralesiD· 1 shared Alice E. StantoniD· 1 shared Alison E. MungenastiD· 1 shared Amanda L. CreechiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Li‐Huei TsaiORCID

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Author profile →

3 papers

Recent·Most cited

Inflammatory reprogramming of human brain endothelial cells compromises blood-brain barrier integrity in Alzheimer's disease

Rebecca L. Pinals, Rezaul Islam, Oisín King, Aaron Choi, Eulim Kang, Masayuki Nakano, Anjanet Tuyeras, Maeesha Tasnim Naomi, Arthur Ngo, Alan Y. L. Jiang, Nhat Truong, Emre Agbas, Claudia F. Lozano Cruz, Colin Staab, Tak Ko, , Li‐Huei Tsai

This study identifies an inflammation-driven gene module in brain endothelial cells that compromises BBB integrity in Alzheimer's disease and shows that an NF-κB inhibitor can reverse these effects.

bioRxiv · Sep 26, 2025 · PreprintNeuroscience

A Photoactivated Protein Degrader for Optical Control of Synaptic Function

Tak Ko, C. Jou, Alejandro Borja Grau-Perales, Martin Reynders, André Antonio Fenton, Dirk H. Trauner

This paper introduces PHOTACs, a method to optically degrade specific proteins in brain tissue, and demonstrates its effectiveness in reducing synaptic function in mice.

bioRxiv · Feb 13, 2023 · PreprintNeuroscience

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations

Lev Litichevskiy, Ryan Peckner, Jennifer G. Abelin, Jacob K. Asiedu, Amanda L. Creech, John F. Davis, Desiree Davison, Caitlin M. Dunning, Jarrett D. Egertson, Shawn B. Egri, Joshua Gould, Tak Ko, Sarah Johnson, David L. Lahr, Daniel Lam, , Jacob D. Jaffe

The paper creates a proteomic resource profiling 90 drugs in six cell lines, revealing cell-specific responses and enabling integration with transcriptional data to identify therapeutic opportunities.

Cell Systems · Apr 1, 2018Peer-reviewedSystems Biology