A microbial metabolite reduces alcohol-induced inflammation via dual modulation of NF-κB and Interferon pathway
Yurui Zheng, Nicholas Lee Handali, Dana Moradi, Colin Varnet, Farhin Patel, Alexander A Aksenov, Adam Kim
This study identifies 4-hydroxyphenylacetic acid (4-HPAA) as a microbial metabolite that enhances interferon signaling and suppresses NF-κB inflammation, reducing alcohol-induced liver injury and lipid accumulation.
bioRxiv · Jun 23, 2026 · PreprintImmunology