Bacterial lipid effectors subvert host autophagic flux by inducing lysosomal dysfunction
Camille Pin, Christelle Marrauld, Priscilla Branchu, Chrystelle Bonnart, Corinne Rolland, Lhorane Lobjois, Simon Lachambre, Frédéric E. Taieb, Éric Oswald, Laure David
This study shows bacterial lipids from HlyF/CprA virulence factors disrupt lysosomal function and autophagic flux, impairing host clearance.
bioRxiv · Sep 22, 2026 · PreprintCell Biology