Age-related increases in PDE11A4 protein expression trigger liquid:liquid phase separation (LLPS) of the enzyme that can be reversed by PDE11A4 small molecules inhibitors
Elvis Amurrio, Janvi Patel, M Danaher, M Goodwin, Porschderek Kargbo, S Lin, CS Hoffman, S Ul Mahmood, DP Rotella, MP Kelly
This study shows that age-related PDE11A4 protein clustering in the hippocampus is due to liquid:liquid phase separation, which can be reversed by PDE11A inhibitors in vitro and in vivo.
Cells · Jun 13, 2025Peer-reviewedNeuroscience