Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation
J. D. Humphries, J. Zha, J. Burns, J. A. Askari, C. R. Below, M. R. Chastney, M. C. Jones, A. Mironov, D. Knight, D. A. O'Reilly, M. J. Dunne, D. R. Garrod, C. Jorgensen, M. J. Humphries
This study identifies integrin α6β4 and hemidesmosomes as critical for PDAC cell proliferation and ECM organization, with implications for therapeutic targeting.
bioRxiv · Aug 19, 2021Cancer Biology