C. Jorgensen

A novel injectable radiopaque hydrogel with potent properties for multicolor CT imaging in the context of brain and cartilage regenerative therapy

This paper develops an iodine-labeled hydrogel for multicolor CT imaging to monitor cell and hydrogel distribution in vivo for regenerative therapy.

PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties

This study identifies PLOD2 as a key factor mediating the chondroprotective and metabolic properties of MRL mouse MSCs in an OA model.

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

This study identifies integrin α6β4 and hemidesmosomes as critical for PDAC cell proliferation and ECM organization, with implications for therapeutic targeting.

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

Clonal Heterogeneity Supports Mitochondrial Metabolism in Pancreatic Cancer

The paper identifies two metabolic subclasses in pancreatic cancer cells and shows asparagine's role in supporting proliferation under mitochondrial stress, suggesting a new therapeutic strategy.

Definition of the fibroblast adhesome using multiplexed proximity biotinylation

The paper defines the fibroblast adhesome using multiplexed proximity biotinylation and identifies functional modules within integrin adhesion complexes.