D. Bajic

Metabolic similarity and the predictability of microbial community assembly

The paper predicts microbial community composition based on metabolic similarities across environments by analyzing growth rates and secretion profiles of proteobacterial strains.

The architecture of metabolic networks constrains the evolution of microbial resource hierarchies

This study uses genome-scale metabolic modeling to show that microbial metabolic hierarchies are constrained by central metabolism, limiting their evolutionary diversity.

Global epistasis and the emergence of ecological function

This study shows that interspecies interactions in ecological communities lead to simple linear models predicting ecological function, analogous to global epistasis in genetics.

Emergent coexistence in multispecies microbial communities

The paper tests whether pairwise coexistence in microbial communities predicts coexistence in complex communities, finding that most species pairs fail to coexist when isolated.

Artificially selecting microbial communities using propagule strategies

The paper uses artificial selection experiments to compare propagule strategies in microbial communities, finding that selected communities achieve higher function than controls in two different experimental setups.

Metabolic rules of microbial community assembly

This study shows microbial community assembly is predictable from metabolic principles, with taxonomic variability explained by competitive exclusion within functional groups.

An antibody-tumor necrosis factor fusion protein that synergizes with oxaliplatin for treatment of colorectal cancer

This paper describes a fusion protein that synergizes with oxaliplatin to treat colorectal cancer, achieving tumor eradication in 40% of mice.

High-order interactions dominate the functional landscape of microbial consortia

The paper shows that high-order interactions dominate the amylolytic function of microbial consortia, making community function unpredictable as size increases.

On the deformability of an empirical fitness landscape by microbial evolution

This study examines how metabolic mutations deform the fitness landscape of E. coli, showing short-range limited effects but long-term legacy impacts on evolutionary trajectories.

Emergent Simplicity in Microbial Community Assembly

The paper shows that microbial communities re-assemble into predictable, stable communities through non-specific metabolic cross-feeding, even when grown in minimal environments.