A. Sanchez

Deep Profiling of Plasma Proteoforms with Engineered Nanoparticles for Top-down Proteomics

This study uses engineered nanoparticles to enrich low-abundant proteins in human plasma, enabling top-down proteomics to detect proteoforms at lower concentrations and expand proteome depth.

Sex-Specific Changes in Cardiac Function and Electrophysiology During Progression of Adenine-Induced Chronic Kidney Disease in Mice

This study examines sex-specific cardiac changes in a mouse model of CKD-induced CVD, finding males show more severe LV dysfunction and altered ECG markers than females.

Caldas meets Janzen: Thermal regimes of montane plants and implications for global patterns of speciation

The paper compares elevational and thermal ranges of sister plant species in tropical and temperate mountains, finding tropical species have narrower thermal ranges and greater similarity between sister species, supporting speciation via thermal specialization.

Full factorial construction of synthetic microbial communities

The paper introduces a low-cost method to assemble all possible combinations of microbial strains, demonstrating it with eight Pseudomonas aeruginosa strains to identify optimal consortia.

Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts

The paper identifies six proteins that predict response to immune checkpoint therapy across three melanoma cohorts and correlate with patient survival.

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

The hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche

This study shows that inhibiting EGFR in hepatocytes reduces liver fibrosis by altering immune cell populations and molecular mechanisms involved in inflammation and fibrogenesis.

Metabolic similarity and the predictability of microbial community assembly

The paper predicts microbial community composition based on metabolic similarities across environments by analyzing growth rates and secretion profiles of proteobacterial strains.

Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases

This study integrates histopathology and proteogenomic data from melanoma metastases to identify subtypes and risk factors, offering a basis for personalized treatment strategies.

Predictability of the community-function landscape in wine yeast ecosystems

The paper predicts community function in wine yeast ecosystems by linking taxonomy to enological traits and showing quantitative rules govern strain contributions to fermentation.

Community ecology of phages on a clonal bacterial host

The paper shows diverse phage communities stably coexist on a clonal bacterial host due to host phenotypic heterogeneity.

Vitamin D deficiency induces erectile dysfunction: role of superoxide

This study shows vitamin D deficiency causes erectile dysfunction by increasing superoxide production in penile tissue.

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

Predictive microbial community changes across a temperature gradient

This study predicts microbial community changes across a temperature gradient by analyzing metabolic responses in synthetic environments.

Macroecological patterns in experimental microbial communities

This study shows that macroecological patterns observed in natural microbial communities also emerge in controlled lab experiments and can be modeled using the Stochastic Logistic Model.

Preliminary Development of a Robotic Hip-Knee Exoskeleton with 3D-Printed Backdrivable Actuators

This paper describes the preliminary development of a modular robotic hip-knee exoskeleton with 3D-printed backdrivable actuators, focusing on design, integration, and potential applications in rehabilitation.

The architecture of metabolic networks constrains the evolution of microbial resource hierarchies

This study uses genome-scale metabolic modeling to show that microbial metabolic hierarchies are constrained by central metabolism, limiting their evolutionary diversity.

Modulation of SLFN11 induces changes in DNA Damage response

This study shows that increasing SLFN11 expression through CRISPR-dCas9 systems enhances DNA damage response sensitivity in breast cancer cells.

Distribution of the invasive Anisandrus maiche (Coleoptera: Scolytinae) in Switzerland, first record in Europe of its ambrosia fungus Ambrosiella cleistominuta, and its new association with Xylosandrus crassiusculus

Learning the functional landscape of microbial communities

The paper introduces community-function landscapes to predict microbial community functions from strain presence/absence, showing they can be accurately trained with limited data and are broadly applicable.

Perturbomics of tumor-infiltrating NK cells

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

Assembly of gut-derived bacterial communities follows "early-bird" resource utilization dynamics

This study shows that gut microbiota assembly follows 'early-bird' dynamics where fast-growing species dominate nutrient sources, and develops a predictive model for community composition based on nutrient inputs.

Environmental modulation of global epistasis is governed by effective genetic interactions

The paper shows that environmental factors, such as drug concentration, can significantly modulate global epistasis patterns in a four-mutation fitness landscape.

Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in Melanoma

This study uses proteomics to analyze mitochondrial function in melanoma samples, finding dysregulation linked to patient survival and treatment responses, and proposes therapeutic strategies targeting mitochondrial pathways.

Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis

This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.

Tracking the emergence and dissemination of a blaNDM-23 Gene in a Multi-Drug Resistance Plasmid of Klebsiella pneumoniae

This study characterizes the emergence and spread of a novel blaNDM-23 gene in a multidrug-resistant plasmid of Klebsiella pneumoniae across Spanish hospitals.

Global epistasis and the emergence of ecological function

This study shows that interspecies interactions in ecological communities lead to simple linear models predicting ecological function, analogous to global epistasis in genetics.

Emergent coexistence in multispecies microbial communities

The paper tests whether pairwise coexistence in microbial communities predicts coexistence in complex communities, finding that most species pairs fail to coexist when isolated.

Chimpanzees organize their social relationships like humans

The paper shows that chimpanzees organize their social relationships similarly to humans, using grooming time as a proxy for relationship intensity.

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.