The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress
E. Fuchs, B. Hurwitz, N. Guzzi, A. Gola, V. F. Fiore, A. Sendoel, M. Nikolova, D. Barrows, T. S. Carroll, H. A. Pasolli
This study shows that the integrated stress response (ISR) redirects translation to centrosomal proteins to clear unfolded proteins at the microtubule organizing center during proteotoxic stress in SCC stem cells.
bioRxiv · Feb 13, 2022Cell Biology