Host-directed therapy with 2-Deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2
L. Wali, M. Karbiener, S. Chou, V. Kovtunyk, A. Adonyi, I. Goesler, X. Contreras, D. Stoeva, D. Blaas, J. Stoeckl, T. R. Kreil, G. A. Gualdoni, A.-D. Gorki
This study shows 2-deoxy-D-glucose inhibits replication of rhinoviruses, endemic coronaviruses, and SARS-CoV-2 in epithelial cells by disrupting viral RNA synthesis and reducing viral load.
bioRxiv · May 24, 2022Microbiology