Author

D. Botman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:yeast· 3 Assay:fluorescence / live-cell microscopy· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

B. Teusink· 3 shared J. Goedhart· 2 shared S. Kanagasabapathi· 2 shared E. Tutucci· 1 shared F. Bruggeman· 1 shared J. H. van Heerden· 1 shared J. van Unen· 1 shared K. v. Rossum· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

B. Teusink

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

cAMP in budding yeast: a messenger for sucrose metabolism?

D. Botman, S. Kanagasabapathi, M. I. Rep, K. v. Rossum, E. Tutucci, B. Teusink

This study investigates how budding yeast adapts to sucrose transitions by analyzing cAMP signaling dynamics and their impact on growth and metabolism.

bioRxiv · Dec 15, 2023 · PreprintMicrobiology

Using the AKAR3-EV biosensor to assess Sch9- & PKA-signalling in budding yeast

D. Botman, S. Kanagasabapathi, B. Teusink

The paper uses the AKAR3-EV biosensor to measure Sch9- and PKA-dependent phosphorylation in budding yeast, revealing homogenous and heterogeneous responses to different nutrients.

bioRxiv · Oct 27, 2022 · PreprintCell Biology

A new FRET biosensor enlightens cAMP signalling in budding yeast

D. Botman, T. G. O'Toole, J. Goedhart, F. Bruggeman, J. H. van Heerden, B. Teusink

The paper develops a FRET biosensor, yEPAC, to measure cAMP signaling in budding yeast and finds that cAMP peaks vary with nutrient transitions and follow Weber's law.

bioRxiv · Mar 21, 2020Microbiology

Palmitoylation of the oncogenic RhoGEF TGAT is dispensable for membrane localization and consequent activation of RhoA

J. van Unen, D. Botman, T. Yin, Y. I. Wu, M. A. Hink, T. W. J. Gadella, M. Postma, J. Goedhart

This study shows that membrane association of TGAT is critical for its activity, but palmitoylation is not required for membrane localization or RhoA activation.

bioRxiv · Aug 9, 2016Cell Biology