Rudimentary Structure-Activity-Relationship study of the MMV Pathogen Box compound MMV675968 (2,4-diaminoquinazoline) unveils novel inhibitors of Trypanosoma brucei brucei DHFR enzyme
D. Dize, R. Tata, R. Keumoe, R. T. Kouipou, M. B. Tchatat, C. Njanpa, V. C. Tchuenguia, L. Y. Tchokouaha, P. V. T. Fokou, B. Laleu, J. Duffy, O. T. Bishop, F. F. Boyom
This study identifies two potent analogs of MMV675968 that inhibit Trypanosoma brucei DHFR with higher potency and selectivity, showing potential as new antitrypanosomal drug candidates.
bioRxiv · May 20, 2022 · PreprintPharmacology & Toxicology