J. Duffy

A Prodrug Strategy to Reposition Atovaquone as a Long-Acting Injectable for Malaria Chemoprotection

This paper develops three prodrug formulations of atovaquone for long-acting injectable malaria chemoprotection, showing two maintain therapeutic plasma levels for over 70 and 30 days in monkeys.

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

The paper screens a compound library against Plasmodium falciparum using a nanoluciferase assay, identifying 33 high-quality hits for antimalarial drug development.

Rudimentary Structure-Activity-Relationship study of the MMV Pathogen Box compound MMV675968 (2,4-diaminoquinazoline) unveils novel inhibitors of Trypanosoma brucei brucei DHFR enzyme

This study identifies two potent analogs of MMV675968 that inhibit Trypanosoma brucei DHFR with higher potency and selectivity, showing potential as new antitrypanosomal drug candidates.

A New Mouse Model of Diffuse Midline Glioma to Test Targeted Immunotherapies

This paper develops a new mouse model of diffuse midline glioma to evaluate IL13R2-targeted immunotherapies, showing tumors with histopathological features of pediatric gliomas.

Lipid chaperone LBP-8 coordinates with nuclear factors to promote longevity in Caenorhabditis elegans

The paper identifies nuclear factors that interact with the lipid chaperone LBP-8 in C. elegans, showing that nuclear import is required for LBP-8's longevity-promoting effects.

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

The paper screens a compound library to identify antimalarial compounds active against multiple Plasmodium life stages and transmission-blocking agents.