Receptor endocytosis orchestrates the spatiotemporal bias of β-arrestin signaling
A. D. Toth, B. Szalai, O. T. Kovacs, D. Garger, S. Prokop, A. Balla, A. Inoue, P. Varnai, G. Turu, L. Hunyady
The study shows that β-arrestin signaling bias is spatiotemporally determined by ligand dissociation rate and G protein activity at endosomes, not receptor conformation.
bioRxiv · Apr 27, 2023Cell Biology