Cell BiologybioRxiv
Receptor endocytosis orchestrates the spatiotemporal bias of β-arrestin signaling
A. D. Toth, B. Szalai, O. T. Kovacs…·L. Hunyady
The study shows that β-arrestin signaling bias is spatiotemporally determined by ligand dissociation rate and G protein activity at endosomes, not receptor conformation.
DOI 10.1126/scisignal.adi0934