B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements
P. Sindaco, S. Lonardi, G. Varano, I. Pietrini, G. Morello, P. Balzarini, H. Neuman, F. Vit, G. Bertolazzi, H. Arima, M. Chiarini, L. Lorenzi, V. Pellegrini, S. Giampaolo, D. Garzon, , S. Casola
This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.
bioRxiv · Jul 13, 2024Cancer Biology