Targeting riboswitches with beta-axial substituted cobalamins
S. R. Lennon, A. J. Wierzba, S. H. Siwik, D. Gryko, A. E. Palmer, R. T. Batey
This study investigates interactions between eleven cobalamin derivatives and three cobalamin riboswitches, showing plasticity and selectivity in RNA-ligand binding with potential for antibiotic development.
bioRxiv · Dec 25, 2022 · PreprintBiochemistry