Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster
A. Hurtado, I. Mota-Gomez, M. Lao, F. M. Real, J. Jedamzick, M. Burgos, D. G. Lupianez, R. Jimenez, F. J. Barrionuevo
This study shows that deleting the miR-17~92 microRNA cluster in XY mice causes complete male-to-female sex reversal by disrupting Sry expression and Sertoli cell differentiation.
bioRxiv · Mar 22, 2023 · PreprintDevelopmental Biology