Directed Biosynthesis of Mitragynine Stereoisomers
C. Schotte, Y. Jiang, D. Grzech, T. Dang, L. Laforest, F. Leon, M. Mottinelli, S. S. Nadakuduti, C. R. McCurdy, S. E. O'Connor
This study identifies the biosynthetic pathway for mitragynine and related alkaloids and uses it to enzymatically produce mitragynine, its epimer, and fluorinated analogues.
bioRxiv · Dec 22, 2022Biochemistry