Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1
D. Dwivedi, D. Harry, P. Meraldi
The paper shows mild replication stress causes premature centriole disengagement in G2 through ATR-Chk1 and subcritical Plk1 activity, disrupting DNA and centrosome cycle synchrony.
bioRxiv · Sep 29, 2022Cell Biology