Author

D. Henry Kates

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Charles L. SawyersiD· 2 shared Jungmin ChoiiD· 2 shared Samir ZaidiiD· 2 shared Achim A. JungbluthiD· 1 shared Afşar BarlasiD· 1 shared Aleksandar ObradovićiD· 1 shared Anuradha GopalaniD· 1 shared Ari J. FirestoneiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Charles L. SawyersORCID

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2 papers

Recent·Most cited

Dependencies in heterogeneous, lineage plastic patient-derived prostate cancer organoids revealed through integrated single-cell multiomics and CRISPR screening

Samir Zaidi, Maren Büttner, Weiran Feng, Caitlin Baxter, D. Henry Kates, Tiago Paiva Prudente, Diana Zakharova, Sanjoy Mehta, Subhiksha Nandakumar, Chen Khuan Wong, Hojin Lee, Pierre-Jacques Hamard, Wenfei Kang, Jungmin Choi, Ronan Chaligne, , Charles L. Sawyers

The paper integrates single-cell multiomics and CRISPR screening in prostate cancer organoids to reveal lineage-specific dependencies and heterogeneity effects on gene essentiality.

bioRxiv · May 8, 2026 · PreprintCancer Biology

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

Samir Zaidi, Jooyoung Park, Joseph Minhow Chan, Martine P. Roudier, Jimmy L. Zhao, Anuradha Gopalan, Kristine M. Wadosky, Radhika A. Patel, Erolcan Sayar, Wouter R. Karthaus, D. Henry Kates, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Linas Mažutis, , Charles L. Sawyers

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Proceedings of the National Academy of Sciences · Jul 5, 2024Peer-reviewedCancer Biology